The Zivak Neonatal LC-MS/MS analysis kit is manually available and not with the Zivak-Multitasker. Additionally, high accuracy is being rectified through external quality tests.
Neonatal screening for dried blood spot LC-MS/MS analysis kit.
Neonatal screening is the most important part of the clinical diagnosis of newborns with inborn errors of amino acid, fatty acid or organic acid metabolism. Expanded newborn screening allows to the diagnosis of over 30 metabolic diseases from a drop of blood samples taken from newborn’s heel with a screening card. This screening test occurred by measurement of some amino acids, free carnitine and acylcarnitines with isotope dilution tandem mass spectrometry. LC-MS/MS is a powerful tool for newborn screening gives results amino acids and acylcarnitines in 1.5 minutes.
Screening of following analytes can be performed with performed by Zivak Neonatal Screening LC-MS/MS Analysis Kit and Zivak NeoZin Newborn Screening software.
By the quantitative analysis of amino acids including alanine, glycine, valine, leucine, ornithine, methionine, phenylalanine, tyrosine, arginine, citrulline, aspartic acid, glutamic acid and argininosuccinic acid, disorders which are related with amino acid metabolism and urea cycle.
By the quantitative analysis of carnitine esters including free carnitine, C2, C4, C6, C8, C10, C12, C14, C16, C18 and C18:1 carnitine, disorders which are related with fatty acid oxidation.
By the quantitative analysis of carnitine esters including C3, C3DC, C4OH, C5, C5OH, C5DC carnitine, disorders which are related with organic acid metabolism.
LC-MS/MS parameters : contact for more details
Storage & Stability:
- This analysis kit can be shipped at room temperature.
- Controls, Reagent 1, 2, 3 should be stored at 2-8 °C.
- All other components of the kit can be stored at room temperature.
- All components are guaranteed until expiry date when stored at recommended temperatures and used as described in these instructions.
Sample Pretreatment (Manual): contact for more details
|
Order No. |
Volume |
Component |
|
ZV-3017-05R1-15 |
1 x 40 ml |
Reagent 1, Contains deuterated internal standards |
|
ZV-3017-05R2-15 |
1 x 12 ml |
Reagent 2, Contains derivatization reagent |
|
ZV-3017-05R3-15 |
1 x 40 ml |
Reagent 3, Contains acid |
|
ZV-3017-05WB-15 |
1 x 0,5 L |
Washing solution, Contains organic solvent |
|
ZV-3017-05MP-15 |
1 x 0,6 L |
Mobile Phase, Contains organic solvent |
|
ZV-3002-KK-15 |
1 x 1 pcs |
User Manual |
| Materials Required But Not Supplied | ||
| Order No. | Volume | Component |
| ZV-3017-02K1-15 | 1 x 1 Spot | Dried Blood Spot Control Level 1 |
| ZV-3017-02C1-15 | 1 x 1 pcs | Zivak Neonatal Screening Dried Blood Spots LC-MS/MS Trap Column Housing |
| ZV-3017-CSPE-15 | 1 x 1 pcs | Neonatal Screening Dried Blood Spots LC-MS/MS Trap Column Cartridge |
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