Quantitative LC-MS/MS analysis kit for Organic Acids in human urine samples.
Organic acid disorders (organic acidemia) are a group of inherited metabolic conditions. Most of the organic acidemias caused by defective autosomal genes for various enzymes for amino acid metabolism. Neurological and physiological harms are caused by this impaired ability to synthesize a key enzyme required to break down a specific amino acid, or a group of amino acids, resulting in acidemia and toxicity to specific organs systems. Most are inherited as autosomal recessive diseases. Organic acid related disorders may affect many metabolic pathways including amino acid, lipid metabolism, fatty acid oxidation and the Krebs cycle.
Organic acidemias are usually diagnosed in infancy, characterized by urinary excretion of abnormal amounts or types of organic acids. The diagnosis is usually made by detecting an abnormal pattern of organic acids in a urine sample. In some conditions, the urine is always abnormal, in the others the characteristic substances are only present intermittently. Many of the organic acidemias are detectable by newborn screening with Tandem Mass spectrometry. These disorders vary in their prognosis, from manageable to fatal, and usually affect more than one organ system, especially the central nervous system.
Quantitative analysis of the organic acids in urine samples have clinical importance for determining organic acidemias and monitoring the organic acid concentrations in human urine. ZIVAK Quantitative Organic Acid LC-MS/MS kit was developed for quantitative detection of the major organic acids in human urine samples. LC-MS/MS is a influential device for the study of metabolic disorders and LC-MS/MS analysis gives results in 20 minutes with minimal sample preparation. Main methods and procedures that we selected are based on EN ISO 13485 and 98/79/EC.
2-3-pyridine carboxylic | Alpha-Ketobutyric Acid | Mandelic Acid |
2-Hydroxyhippuric Acid | Alpha-Ketoisocaproic Acid | Methylmalonic Acid |
2-Hydroxyphenylacetic acid | Alpha-OH-butyric acid | Methylsuccinic Acid |
2-Ketoglutaric Acid | Benzoic Acid | Mevalonolactone |
2-me-hippuric | Beta-OH-isovaleric Acid | N-(3-Phenylpropionyl) glycine |
2-Methylcitric acid | Cis-aconitic Acid | N-Acetyl-L-aspartic Acid |
2-Methylglutaric Acid | Citramalic Acid | Orotic Acid |
3,4-dihydroxy-hidrocinnamic Acid | Citric Acid | Phenylacetic Acid |
3-Hydroxy-3-methylglutaric Acid | D-Saccharic acid potassium salt | Phenylglyoxylic Acid |
3-Hydroxybutyric Acid | Ethylmalonic Acid | P-Hydroxyphenyllactic Acid |
3-Hydroxypropanoic Acid | Formiminoglutamic Acid | Picolinic Acid |
3-Indoleacetic Acid | Fumaric Acid | Pimelic Acid |
3-me-hippuric Acid | Furan-2,5-dicarboxylic Acid | Propionyl Glycine |
alpha-ketoisovaleric acid | Glutaric Acid | Pyroglutamic Acid |
3-Methyl-2-oxovaleric Acid (AKBM) | Glycolic Acid | Pyruvic Acdi |
3-Methylcrotonyl Glycine | Glyceric Acid | Sebacic Acid |
3-Methylglutaric Acid | Hexanoyl Glycine | Suberic Acid |
3-Oxoglutaric Acid | Hippuric Acid | Suberyl glycine |
3-Phenyllactic Acid | Homovanillic Acid | Succinic Acid |
4-Hydroxybenzoic Acid | Isocitric Acid | Tartaric Acid |
4-Hydroxyphenylacetic acid | Iso-Valeryl Glycine | Tiglyl Glycine |
4-Methylhippuric Acid | Kynurenic Acid | Tricarballyl |
5-Hydroxyindole-3-acetic acid | Lactic Acid | Vanilmandelic Acid |
Adipic Acid | Malic Acid | Xanthurenic Acid |
Alpha-Hydroxyglutaric Acid | Malonic Acid | α-Hydroxyisovaleric Acid |
LC-MS/MS parameters : contact for more details
Pre-analytic Treatment: contact for more details
Preparation of Calibrators & Controls contact for more details
Kit Content: contact for more details
© 2024 Zivak. All Rights Reserved.